There was a great article in the travel section of the New York Times a few days ago about following in the footsteps of the Pilgrims from England and the Netherlands to Massachusetts.
The 102 passengers who sailed on the Mayflower in September 1620 came from all over England (and not all of them were religiously motivated), but the leaders of the separatist movement came from just a handful of farming villages in Lincolnshire, Nottinghamshire and southern Yorkshire, most within walking distance of one another. This is not the touristy, thatched-cottage part of England, but it is beautiful nonetheless, and last spring my wife and I visited to see what we could learn about her ancestors, who in so many ways are forefathers to us all.
It's a great overview of this important period in history, even if you don't have ancestors who broke bread at the first Thanksgiving. Worth a look.